Amander Clark PhD is an Australian born, American stem cell biologist specializing in pluripotency and germline cell differentiation. Her laboratory was the first in the world to isolate prenatal human germline cells for genomic analysis, and to identify the stages of human prenatal germline epigenetic reprogramming at single base resolution. Results from the Clark Laboratory provide the fundamental basis for translational projects related to in vitro gametogenesis (IVG), germ cell tumors and health outcomes in offspring. Dr. Clark is Professor and Chair of the Department of Molecular Cell and Developmental Biology, she is a key member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and is a member of the executive committee for the International Society for Stem Cell Research. Dr. Clark is a recipient of a Young Investigator Award from the Lance Armstrong Foundation, a Research and Career Development Award from STOP Cancer, a Research Award from the Concern Foundation and a Young Investigator Award from the International Society for Stem Cell Research. Dr. Clark is a member of the Hinxton Group, an International consortium of scientists, ethicists and policy makers responsible for generating position statements that affect policy for the use of pluripotent stem cell derived gametes and germline genome editing in human embryos.
Dr. Clark’s work in stem cell biology began in 2002 as a Postdoctoral fellow in laboratory of Dr. Renee Reijo Pera at the University of California, San Francisco (UCSF). There, she studied not only the basic biology of human embryonic stem cells but also the molecular mechanisms of human germline cell formation. During that time only a small number of laboratories worldwide were performing research with human embryonic stem cells because of the technical challenges with expanding and differentiating these cells, and the uncertain International policy climate for research in this area. Despite these challenges, Dr. Clark and Dr Reijo-Pera were the first to report that human germline cells could be differentiated from human embryonic stem cells. This landmark paper has been cited more than 600 times and was used as the basis for Dr. Clark’s research program at UCLA.
Dr. Clark joined the UCLA faculty in 2006 as an Assistant Professor, was awarded tenure in 2012, Associate Professor and Vice Chair in 2013, Professor and Vice Chair in 2014 and Chair of the Department in 2017. Dr. Clark is particularly interested in generating germline cells from stem cells in order to model fertility, infertility and early pregnancy loss. Dr Clark has authored more than 100 articles in her career and her work has earned more than 12,000 citations.
Dr Clark considers herself very fortunate that her work has been supported by the National Institutes of Health, Bill and Melinda Gates Foundation, W.M. Keck Foundation, California Institute for Regenerative Medicine, UCLA Broad Stem Cell Research Center, STOP Cancer, Lance Armstrong Foundation, Fuller Foundation, UCLA Iris Cantor Women's Health Center, and the Lalor Foundation.
Box 957246, Department of Molecular, Cell and Developmental Biology, UCLA
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